The Proportion Cured of Patients with Resected Stage II-III Cutaneous Melanoma in Sweden

Cure proportion represents the proportion of patients who experience the same mortality rate as the general population and can be estimated together with the survival of the proportion experiencing excess mortality (the uncured). The aim was to estimate the cure proportions and survival among uncured stage II-III cutaneous melanoma (CM) patients. 1- and 5-year relative …
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The role of local therapy in the treatment of solitary melanoma progression on immune checkpoint inhibition: A multicentre retrospective analysis

In patients with metastatic melanoma, progression of a single tumour lesion (solitary progression) after response to immune checkpoint inhibition (ICI) is increasingly treated with local therapy. We evaluated the role of local therapy for solitary progression in melanoma. Patients with metastatic melanoma treated with ICI between 2010 and 2019 with solitary progression as first …
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Pembrolizumab Plus Ipilimumab Following Anti-PD-1/L1 Failure in Melanoma

Combination of antiprogrammed cell death protein-1 (PD-1) plus anti-cytotoxic T-cell lymphocyte-4 (anti-CTLA-4) immunotherapy shows greater response rates (RRs) than anti-PD-1 antibody alone in melanoma, but RR after initial anti-PD-1 and programmed death ligand-1 (PD-L1) antibody progression awaits robust investigation. Anti-CTLA-4 antibody alone after anti-PD-1/L1 …
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PET-CT for staging pT4b melanomas prior to sentinel lymph node biopsy: a 5-year review

In this centre, patients with pT4b cutaneous melanoma are staged using 18F-FDG PET-computed tomography (PET-CT) prior to considering sentinel lymph node biopsy (SLNB). The objective was to assess the utility of PET-CT in terms of rates of detection of metastases leading to changes in planned treatment and if performing PET-CT was associated with a delay in …
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Influenza vaccination in cancer patients receiving immune checkpoint inhibitors: A systematic review

There is a concern that influenza vaccination may increase the incidence of immune-related adverse events in patients receiving immune checkpoint inhibitors. The aim of this systematic review was to summarize the available data on the safety and efficacy of influenza vaccination in cancer patients receiving immune checkpoint inhibitors. Studies reporting safety and efficacy …
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