Treatment of Metastatic Colorectal Cancer: ASCO Guideline

To develop recommendations for treatment of patients with metastatic colorectal cancer (mCRC). ASCO convened an Expert Panel to conduct a systematic review of relevant studies and develop recommendations for clinical practice.Five systematic reviews and 10 randomized controlled trials met the systematic review inclusion criteria.Doublet chemotherapy should be offered, or triplet therapy may be offered to patients with previously untreated …
Continua a leggere

Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

Colorectal cancer (CRC) is the third most common cancer worldwide, with 1.1 million new cases per year, and is the second leading cause of cancer death. CRC occurs more frequently in middle- to high-income countries with an eightfold variation in incidence across the world. This rise may be associated with known risk factors, including alcohol intake, tobacco use, obesity, sedentariness and dietary patterns …
Continua a leggere

Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C

Adagrasib, an oral small-molecule inhibitor of mutant KRAS G12C protein, has shown clinical activity in pretreated patients with several tumor types, including colorectal cancer. Preclinical studies suggest that combining a KRAS G12C inhibitor with an epidermal growth factor receptor antibody could be an effective clinical strategy. In this phase 1-2, open-label, nonrandomized clinical trial, we assigned heavily pretreated patients …
Continua a leggere

Prognostic Impact of Early Treatment and Oxaliplatin Discontinuation in Patients With Stage III Colon Cancer: An ACCENT/IDEA Pooled Analysis of 11 Adjuvant Trials

Oxaliplatin-based adjuvant chemotherapy in patients with stage III colon cancer (CC) for 6 months remains a standard in high-risk stage III patients. Data are lacking as to whether early discontinuation of all treatment (ETD) or early discontinuation of oxaliplatin (EOD) could worsen the prognosis. We studied the prognostic impact of ETD and EOD in patients with stage III CC from the ACCENT/IDEA databases …
Continua a leggere

Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death

Although colonoscopy is widely used as a screening test to detect colorectal cancer, its effect on the risks of colorectal cancer and related death is unclear. We performed a pragmatic, randomized trial involving presumptively healthy men and women 55 to 64 years of age drawn from population registries in Poland, Norway, Sweden, and the Netherlands between 2009 and 2014. …
Continua a leggere