GIORNATA DELL’ADERENZA ALLA TERAPIA

AL VIA LA TERZA GIORNATA NAZIONALE PER L’ADERENZA ALLE TERAPIE CIAT E SENIOR ITALIA FEDERANZIANI “7 PAZIENTI SU 10 NON ASSUMONO CORRETTAMENTE I FARMACI”

Roma, 12 aprile 2021 – In occasione della ricorrenza della morte del campano Giuseppe Moscati (il “Santo Medico” deceduto il 12 aprile del 1927) si celebra oggi la terza Giornata Nazionale per L’Aderenza alle Terapie. In Italia ben sette pazienti su dieci, colpiti da una o più malattie croniche, non assume i medicinali nei tempi e nelle modalità indicate dal personale sanitario. Da qui l’esigenza di promuovere iniziative per contrastare un fenomeno francamente preoccupante e che la pandemia ha contribuito ad incrementare. Per questo è nato CIAT: il Comitato Italiano per l’Aderenza alla Terapia che riunisce 20 Società Scientifiche e rappresentanti di pazienti, istituzioni e medici FNOMCeO-Federazione Nazionale degli Ordini dei Medici Chirurghi e degli Odontoiatri; farmacisti di Federfarma e infermieri FNOPI -Federazione Nazionale Ordini Professioni Infermieristiche)…continua a leggere

ARTICOLI DALLA LETTERATURA SCIENTIFICA

Polypill for Cardiovascular Disease Prevention in an Underserved Population
Feagan BG, Rutgeerts P, Sands BE, Selinger CP, Parkes GC, Bassi A

To the Editor: In the article by Muñoz et al. (Sept. 19 issue),1 the authors describe one of the first clinical trials testing the use of a polypill for cardiovascular disease prevention in an underserved population with a positive outcome. The concept of using a polypill in a general patient population warrants caution owing to pharmacogenetic differences among individual persons with respect to the components of the polypill. Several studies have shown great interindividual variability in drug response and treatment benefit as well as in side effects. In PERGENE (Perindopril Genetic association study), a large-scale pharmacogenetic substudy of EUROPA…Read more

Ultra-low-dose quadruple combination blood pressure-lowering therapy in patients with hypertension: The QUARTET randomized controlled trial protocol
Clara K Chow, Emily R Atkins, Laurent Billot, John Chalmers, Graham S Hillis, Peter Hay, Bruce Neal, Mark Nelson, Anushka Patel, Christopher M Reid, Markus Schlaich, Tim Usherwood, Ruth Webster, Anthony Rodgers

High blood pressure is the leading cause of preventable morbidity and mortality globally. Many patients remain on single-drug treatment with poor control, although guidelines recognize that most require combination therapy for blood pressure control. Our hypothesis is that a single-pill combination of 4 blood pressure-lowering agents each at a quarter dose may provide a simple, safe, and effective blood pressure-lowering solution which may also improve long-term adherence. The Quadruple UltrA-low-dose tReaTment for hypErTension (QUARTET) double-blind, active-controlled, randomized clinical trial will examine whether…Read more
 

Interventions supporting long term adherence and decreasing cardiovascular events after myocardial infarction (ISLAND): pragmatic randomised controlled trial
Noah M Ivers, Jon-David Schwalm, Zachary Bouck, Tara McCready, Monica Taljaard, Sherry L Grace, Jennifer Cunningham, Beth Bosiak, Justin Presseau, Holly O Witteman, Neville Suskin, Harindra C Wijeysundera, Clare Atzema, R Sacha Bhatia, Madhu Natarajan, Jeremy M Grimshaw

Objective: To test a scalable health system intervention to improve long term adherence to secondary prevention treatments among patients who have had a recent myocardial infarction.
Design: Three arm, pragmatic randomised controlled trial with blinded outcome assessment.
Setting: Nine cardiac centres in Ontario, Canada.
Participants: 2632 patients with obstructive coronary artery disease after a myocardial infarction, identified from a centralised cardiac registry.
Interventions: Participants were randomised 1:1:1 to receive usual care…Read more
 

Adherence to cardiovascular prevention principles in subjects at high risk
Otto Mayer Jr, Jan Bruthans, Julius Gelžinský, Markéta Mateřánková, Štěpán Mareš, Veronika Svobodová, Jitka Seidlerová, Renata Cífková, Jan Filipovský

Background: Asymptomatic high-risk individuals represent one of the highest priorities of cardiovascular prevention, in clinical practice frequently overlooked. We analyzed the real adherence to recommended principles of cardiovascular prevention in primary care subjects.
Methods: Our analysis is based on random general population sample, examined in the frame of post-MONICA survey in 2016/17. Each subject was categorized with regard to its individual cardiovascular risk (based on Sixth Joint European Guidelines) and the real adherence to recommended targets was ascertained…Read more

Assessing reported adherence to pharmacological treatment recommendations. Translation and evaluation of the Medication Adherence Report Scale (MARS) in Germany

Cornelia Mahler, Katja Hermann, Rob Horne, Sabine Ludt, Walter Emil Haefeli, Joachim Szecsenyi, Susanne Jank

Objectives Patients’ self-report of medicine taking is a feasible method of assessing their adherence to prescribed pharmacological treatment. Aim of this study was to assess whether the German version of the Medication Adherence Report Scale (MARS-D) is an appropriate instrument for measuring patient adherence. Methods After translation into German, the questionnaire was sent to 1488 patients with chronic diseases and patients with risk factors of cardiovascular disease. Reliability and validity of the MARS-D were assessed and compared with the psychometric properties of the original English version. The relationship…Read more

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